The VAF2 is for a number of specific types of visas, which are outside the regular sponsored work visa categories:
- Domestic workers
- Contract seaman
- Representative of overseas business
- Clinical attachments
- Film crew on location
- Overseas qualified doctors taking the PLAB test
- Postgraduate doctors and dentists
See here for more information on how to qualify for any of these:
http://www.ukba.homeoffice.gov.uk/visas-immigration/working/othercategories/Or, the VAF2 is used if you are the family member of someone who has temporary permission to live and work in the UK as a migrant worker, but they are not under the points system (points system visas include: Tier 1 or Tier 2 work visas, Tier 4 student visas, Tier 5 temporary work visas etc.).