If your wife is a UK citizen and you wish to move to the UK together, you may be able to qualify for a UK spousal visa. This visa would allow you to work in the UK without needing a work visa, based on your marriage to a UK citizen.
However, you would have to meet the strict financial requirements in order to qualify for it - and most of the financial requirement is based on your wife's income that she is or will be earning IN the UK.
Your current US or future UK income cannot be considered towards the financial requirements unless you have a visa that gives you permission to work in the UK (either a spousal visa or a work visa).
There are several ways to meet the financial requirement for a spousal visa:
Category A: Current UK Employment - more than 6 monthsYour wife has been working
in the UK, earning a minimum salary of £18,600 per year (approx. $31,000) for at least 6 months.
Category B: Current UK Employment - less than 6 monthsYour wife has been earning a minimum salary of £18,600
in the UK for less than 6 months AND she has also earned at least £18,600 in the previous 12 months before applying for the visa.
or
Your wife has a guaranteed job offer in the UK earning at least £18,600 and starting within 3 months of you moving to the UK together AND she has also earned at least £18,600
in the US in the previous 12 months before applying for the visa
Category C: Non-employment incomeEither you or your wife have current non-employment income totalling £18,600 per more per year, you have been receiving it for at least 12 months, and it will continue while you are in the UK. For example, rent from property you own, income from dividends, stocks and shares, interest from savings etc.,
Category D: Cash SavingsIf your wife is not/will not be working in the UK, you need to have £62,500 (approx. $100,000) in cash savings to meet the requirement, and the entire amount must have been held in your personal bank account(s) for at least 6 months before you can apply for the visa.
Category E: PensionPensions received by you or your wife for at least 28 days and totalling at least £18,600 per year
Category F and G: Self-Employment IncomeYour wife is self-employed and has earned an average of either £18,600 in the last financial year (Category F) or last 2 financial years (Category G).
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If you can't meet any of these Category requirements, then basically your only option to move to the UK would be to qualify for a skilled work visa.
Then, you could work in the UK (but your visa would be tied to that specific job) and once you could meet one of the spousal visa financial requirements with your UK income, you could apply to switch to a spousal visa from inside the UK.
Work visas unfortunately can be extremely difficult to qualify for.
The company would have to prove that either the job was listed on the
Tier 2 Skills Shortage List or that they had advertised the job across the UK and EU for a certain length of time and found no suitable applicants, before they could hire you... and with 500 million people in the EU and unemployment still high, it would have to be a very highly skilled or unusual job in order for there to be no one at all, except you, qualified to do it.
Alternatively, if you work for a US company with offices in the UK, you may be able to transfer on an Intra-Company Transfer work visa - but there are specific requirements for that too (length of service, your position within the company etc.).
See here for more information about spousal visas:
http://www.ukba.homeoffice.gov.uk/visas-immigration/partners-families/citizens-settled/spouse-cp/and work visas:
http://www.ukba.homeoffice.gov.uk/visas-immigration/working/tier2/general/http://www.ukba.homeoffice.gov.uk/visas-immigration/working/tier2/ict/