IMHO, some who simply can't adjust never consider the UK to be 'home'. When I initially came to the UK back in the early 90s, I made the decision to make this country my home. I didn't try to make it like the US, nor did I constantly make comparisons about how different life is here. For me, that would have been a slippery slope.
Now, after being in Portugal for a brief period in the late 90s, back to the UK, and then to the US for 11 years (totally for economic reasons - long story), I am firmly settled here. I don't anticipate ever returning to the US to live; I much prefer life here.
Occasionally I have to remind DH that to me, the thing one puts on the floor to catch paint spatters is a drop cloth, and that a dust cloth is what I use to remove dust from furniture. It's a vacuum cleaner, and I vacuum the floor - I don't 'hoover it'. When he's in a mood, even after all these years he will play the 'deliberate misunderstanding word game'. I've learned to live with that.
I won't say it's not difficult, but I will say that during the past few years when I made the trek to visit aging parents, each time it struck me how much the US had changed. Life as I once knew it was definitely not the same, even in the little NC town where I grew up.
The period of adjustment is unique to each of us, and definitely affected by employment, friendship groups, and all the other things that would affect a person who might move anywhere that's different. For example, if your wife moved from LA to a tiny town in South Dakota (no offense to that state), it would be a culture shock. Just be understanding, and non-judgmental, as I am sure you will be.