Hey Lisa,
Have a great time. I went to school there and absolutely adore it. Don't miss out on Villa Borghese it's a nice walk through the park. That's near Piazza Del Popolo, at the beginning of the park and the piazza. In the center of Piazza del Popolo there is an obelisk was brought from the Massimo Circus (something to that effect). Then if you're facing the entrance of PDP there's a beautiful small Church of 'Santa Maria del Populo' that not many tourist pay attention to because is not one of your better known churches. If my memory serves me right there are two awesome pictures by Caravaggio (the ones I remember) are the "Conversion of Saint Paul" and "The Crucifixion of Saint Peter". THere are also two other churches in that same area but I can't remember the name of them. I think Bernini has some more artwork there (where does he NOT have artwork in Rome
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Of course the Vatican!! That's a whole day within it's self. If you do go inside remember your shoulders cannot be exposed as well as any your legs (miniskirts, shorts, mid-driff, stuff like that). They might have relaxed the dress code there while it's summer 'cause it gets sooo hot there. Just a guess, I don't know 'cause when I was there it was from December to May. But I do remember I had a skirt on with boots when I first went and I could not go in
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The Castel Sant' Angelo is an awesome site (one of my favorites) also if you're an arts/music fan you've got to go to Piazza Navona. That was one of my hangouts when I went to school there. Gorgeous fountains by Bernini, artists and muscians all around. The main cafes that surround the area are quite touristy and pricey but it's nice to have a glass of vino there, hang out and just people watch. Also in the Forum there is a off-the-beaten path where there's a little garden area that's great for a picnic. I can't remember exactly where it is but I believe it's past the area of the Vestal Virgin statues. The Trevi Fountain is another place you should not miss. While you're there you need to throw some coins in the fountain, the theory goes that when you do throw a coin or two, you'll return to Rome.
Via Conditti is a popular street there and it meets up with two of the other main streets in Rome: Via del Corso and Via del Babuino (spl??). There is where you'll find a lot of good shopping also that's where you'll find the courture designers in abundance.
I have a friend there who owns a bar called the Drunken Ship who I met while going to school there. His name is Brian. You should pop in for a drink. The bar is located at Piazza Campo de Fiori, 20 (near the Pantheon). If you do go, would you give him my love and my best.
I will try and see if I still have my list that I had saved of trattorias that are not known to the tourists but the locals (which are always the best places to go, if you're interested) that I compiled while living there. Or if you do go for a drink at the Drunken Ship ask Brian he'll definitely know a lot more places than me (since it's been ***a long time*** since I've actually lived there.
Watch out for the gypsies especially the little tykes that run around the Spanish Steps and in the metro!! They usually run in packs.
Enjoy your weekend.