Ok - I've been watching this post and I didn't want to say anything earlier because of the view most people seem to have of people who have tried Alli (orlistat) but I'm going to come out and say that yeah - I tried it! And I did NOT have any "leakage" or "explosions" of any kind! No rubber underwear or diapers needed! Granted, I was working out and following weight watchers as well as making sure that my meals didn't have more than whatever grams of fat (15g?) they said to avoid. But I wasn't trying to use a "magic" pill to lose weight without effort - I was just trying to supplement my efforts at weight loss (which I have found to be a really difficult process - I don't know if its my genes or whatever - yay for being Hispanic, but even with a personal trainer and following weight watchers religiously it took me AAAAGES to drop weight). Which is how I think the pill is meant to be used - to try and help decrease the absorption of fat, when you are already doing what you can to lose weight traditionally.
Now, whether it works or not is clearly debated heavily - but I got a vial of the pills at a highly reduced cost and I thought it was worth it. I didn't use them long term (didn't feel like putting out more money for something that may have been questionable) but like I said before, there weren't any "nasty" side effects apart from yes, some oil in the stool but it wasn't noticeable until it was already - well, out of me.
I think its not such a big deal if people use it the way it is meant to be used.