Grocery shopping which, as has been mentioned, Oyster card/travel card, sorting out the bank situation, library card, new keys, and learning where the basics are (post office, grocery shops, smaller food shops, cafe (especially important if you're living with family and need an escape hidey hole), a local pub (important even if you don't drink much), doctor and dentist, vet if you have pets.
In smaller areas, a big effort might not be that important, but I think not only does it help people find their way around, it helps people get used to an area. In my case, I am not from anywhere that had a lot of samey samey housing. When I moved to Westminster which has a lot of Cubitt designed housing which most of the time hasn't been modified much on the outside from the early 1800s, I would get totally disorientated. Now, I am totally used to it, and I think the buildings (and even streets) look very individual. People from places with a lot of subdivisions might not have this problem, but those of us who aren't, might need a little extra adjustment.