I moved here from Orlando as well in April 2008. I live in Wolverhampton, just outside of Birmingham. I agree with everyone else, the weather is the biggest adjustment for a native Floridian. The first winter wasn't too bad because the snow and cold was different and a little exciting. Last winter, though, was even more snow and cold and not so exciting. Although the snow is still nice, if you don't have a car and have to travel a lot, it isn't much fun!! The other things to get used to are the foods tasting different, especially the deserts, buying groceries and the stores closing early, especially on Sundays. Anyway, despite all of this, I absolutely love it here and, although I miss the wonderful Florida weather, it was worth the move!!
Good luck and just stay positive. Think of all of the differences as a new adventure and not don't focus on how it is different from home and things will go much more smoothly for you!!