(IMHO) In most instances, a stocks and shares ISA will cause complications on a US return (pooled foreign funds). If it's individual stocks or shares you purchase, it may ease the US burden, but have you found any such products (truly purchased and owned by the individual) within a certified ISA wrapper? As you are aware, any ISAs (of whatever variety) are deemed taxable in the US. Only a suggestion, but if you desire stocks and shares, it may be easier to forget about the ISA wrapper altogether and investigate ramifications for both the US and UK taxation of self purchased individual stocks and shares, and which ones may have an advantage.