I guess it depends on where you are coming from.
I am very used to driving on narrow winding roads (coming from a rural mountain town, many places were not excatly straight, wide, paved roads).
Manual transmission? I've always driven a "clutch". Of course, being left-handed, it is a lot nicer in the UK.
As for the wrong side of the road? Well, it's just nice to know that you won't get a ticket for it in the UK, where in the states you get a sobriety test for driving on the left!
Gas prices? Well, you don't drive as much as in the states so it balances out. Car sizes? In addition to my "farm truck" and other big rigs used in a rural farming community, my little Honda CRX took me places, so I'd say I'm used to the small cars, too.
What I am not used to is the limited parking in the city! I never knew that parking could be such an issue!