You don't owe tax in the UK on the sale of a primary residence, so that chunk of change is not an issue.
For all other cash you have, the set point begins the day you move. You can take as much $$££ with you as you like with no UK tax consequences. If, once you have moved, you sell a stock in the US, as a repatriated Brit you will probably be UK domiciled, and thus owe tax on the capital gains in the UK. It may make sense for you to sell some of your "winners" before you become UK resident. I recommend a tax-planning session with a dual qualified US/UK tax expert to plan which, if any, assets to divest and the timing of any such divestments. If you don't have a lot of stocks outside of pensions and IRAs, it's not an issue.