I saw it because it got such good reviews but it was just awful - really geared towards slacker men rather than women. And not funny. The audience was silent. 
At Knocked UP? Wow, our audience was in tears laughing the whole time. The ladies, the men, all of us. My sister and her friends too, who all told us to see it.
I thought 40 year old Virgin was ehh, I think it was all the hype involved in it though, that always happens to me if I hear to much before I see something.