I have not read all of the posts here yet, but I can speak to the friendship aspect, and I am relieved I'm not the only one finding it hard to make friends here!
I see that my husband has had the same friends that he grew up with since he was four, and he is amazed at how fickle American friendships can be (only one of mine has persisted strongly since I've been in the UK). Meanwhile, I have yet to find intimate conversations with girls over here without a strong feeling of encroachment and ridicule (does anyone else sense that prevailing attitude of 'I'm too good/hot to talk to you'??). They are polite on the surface, but it is very difficult to be transparent within a culture where privacy reigns supreme. I respect those boundaries, but my open nature is often stilted by this lack of contact with anyone other than my husband.
I also identify with missing my family, ironically, the very thing I was excited about leaving since they are the source of my life's biggest drama. I come from a family of 7 siblings and a few nieces and nephews, and I do miss them immensely. (Also, Wegmans, as I am from the city where the grocery chain is headquartered! Tesco just doesn't compare!!)
On the other hand, in my first 3 months as a wife here, I am grateful for things that we lack in the States, like a great public transport system, shops within walkable distance, local pubs in every village, the way religion isn't forced down your throats, and friends who--once you befriend them--are yours for life. Beyond that, I do look at my husband and realize that I love him enough to give up those things that I miss--and he's the only reason I'd do it all 100 times over if it ever came to it.