There are loads of amazing things to do. What do you like?? What kind of food do you like?
Swissotel is basically in the middle of the big shopping areas - Michigan Avenue is the Mag Mile, with the typical shops, and you could just walk up and down that to find anything you want. You are also very close to Navy Pier and the lake, you could do a boat cruise on the lake/river which is beautiful. There are loads of good restaurants in that area as well. And you are within walking distance of the John Hancock tower, which is one of the tallest buildings. If you've never done that or Sears Tower, you might want to go to one of those. Chicago style pizza is a good bet - Pizzeria Uno, Due, or Lou Malnati's are relatively close.
If you like museums, you could go south to the Adler Planetarium, Shed Aquarium, or the Field Museum of Natural History.
Hmm...I will have to think of what I would consider to be a perfect 24 hours in Chicago !