oooh love this thread! Right up my alley.
I found so many good suggestions, and also kindred spirits. ( a shout of to LM Montgomery readers)
I listed my favorite books a while ago on my blog, here's a copy.
1. Middlesex By Jeffrey Eugenides- So good, about a young person who discovers that they are a hermaphradite. It details his family history, and the reasons behind his disorder.
2. Black and Blue By Anna Quindlen- A story of an abused wife, I read it in an evening and have rarely cried so much from a book. Amazing.
3. Daisy Fay and the Miracle Man By Fannie Flagg- I've loved this book since my pre-teens. A story about a young girl coming of age in the south and her father's money misadventures.
4. Dry By Augusten Burroughs- Oh my goodness- this book really put me off the sauce. A witty and somehow hilarious memoir about alcoholism.
5. Marley and Me By John Grogan- If you own a lab, or a dog that you really adore this is the book for you. The tag line is "life and love with the world's worst dog," and you'll cry your eyes out at the ending.
6. The Pact By Jodi Picoult- Kim started me on Jodi Picoult and I've now read most of her stuff. This book is so amazing and beautiful and sad. It's about 2 young lovers that make a suicide pact, but one of them survives.
7. The Red Tent By Anita Diamant- Kind of a girls book, a fictional account on the sole daughter of the biblical character Jacob.
8. The Handmaid's Tale By Margaret Atwood- The first Atwood book I read. I stayed up until four a.m. as I couldn't put it down.
9. Plain Truth By Jodi Picoult- Another Jodi Picoult book- this one about an Amish girl on trial for murder. So good.
10. Sideways By Rex Pickett- You've probably seen the movie, but I really preferred the book. Groom and best man visit the wine country before the big day. Hilarity ensues.
11. The Lord of the Rings Trilogy By JRR Tolkien- Wow, I can't get enough of these books. I first heard them on tape on a trip cross country with the fam and have since read them several times. I enjoy the movies, but again not even a comparison with the books. Tolkien was a genius.
12. All of the Anne books by L.M. Montgomery- Ahh, the Anne books are my comfort food. All L.M.'s books are lovely but these are my real favorites of the bunch.
13. Maus I and II By Art Spiegelman- Comic books detailing the holocaust. Sounds gruesome, but they really are quite amazing, and should be required high school reading.
14. Wuthering Heights By Emily Bronte- Read this on a rainy cloudy day in front of the fire. I've seen every movie version of this and nothing compares to the novel, this is a top five fave.
15. Pride and Prejudice By Jane Austen- I know it sounds totally pretentious to like Austen, but no more so than this list. I love all of her books (that I've read) but this one is certainly my favorite. I think Mr. Darcy is among my favorite literary characters.
16. Rachel's Holiday By Marian Keyes- I have to follow the Austen with something trite, and this book is one of my favorites of that genre. A funny fictional account of a a girl going through rehab.
17. Geek Love By Katherine Dunn- Super creepy story about a carnival family and their machinations to stay in business. You can't read this book while eating.
18. My Year of Meats By Ruth Ozeki- I love Ruth Ozeki in general but this novel (based on fact) caused me to stop eating meat for almost a year. Chew on that.
19. My Sister's Keeper By Jodi Picoult- I know I've already mentioned a couple of her books, but Jodi P. is among my most favorite authors. A book about a sister born to save her older sister from dying of leukemia. Another tissue box needed novel.
20. Naked By David Sedaris- I love all of David Sedaris' work, but this book cracked me up the entire time. His books are actually best by audiobook, so I would suggest getting them off I-tunes.
*21. Under the Banner of Heaven By Jon Krakauer- Crazy non-fiction book about a fundamentalist mormon group. So chilling, and another I stayed up all night reading.