I think I've been flagged or something by the tsa or something, because for the past 3-4 years I've gotten search every time I fly. Sometimes they nicely have everything back like I had it, still in the bags.
I put all my liquids (hair stuff, soap, deodorant, toothpaste, etc) in plastic ziplock bags.
A couple times I've been searched and they dumped out the liquid bags into the suitcase.
Which resulted in sunscreen exploding all over everything on one trip, and another time my expensive anti-frizz hair stuff spilling out on my brand new tennis shoes.
I had to take everything out of my backpack when going through security when coming back from Mexico. I had everything packed in there so tight the x-ray machine couldn't see through it. That was a nightmare - I had tons of breakables and they were all wrapped in layers bubble wrapped.
But I've never had anything go missing.
And searches are random, so you have a fairly good chance of not getting searched!