I'm in the "pro" camp on Confederacy of Dunces....
Oh, and twisted, there are two tricks to Ulysses (I did my BA in Irish lit.) First, read it for the gorgeousness of the language without trying to understand what's actually going on. Second, if you're determined enough to read two books at once (I wouldn't be now, but at 20 I was willing) there's a book called Joyce Annotated that explains it pretty much line-by-line - so if you read a line that doesn't make sense you can look at the annotation and it gives you definitions and brief explanations and whatnot....
Barring that, get a copy of Kate Bush's The Sensual World and listen to the title track a lot. Yes I will, Yes I said, Yes. Lovely.