We have a 2 bed terraced house. I used to have the box in the bathroom (which is downstairs in an extension), then it was in the kitchen until we had that redone. Now it sits in front of the back door (in the extension) and moved when we need to go out for the bins etc, to the other side of the hall but that blocks the doorway to the cupboard where the boiler and dryer is!
My cat always used to go out and didn't need a litter box (as we have a cat flap) until a few years back when a neighbour had a big Alsatian dog, although the fence was such that it couldn't get over, the cat would have to walk close to the fence and was just scared to go out. So even though they've moved she rarely goes out now, and she is getting on now (she's 18!)