Hiya, I used Quicken and Microsoft Money in the past to manage my finances. When Microsoft stopped supporting Money, I migrated to Mint.com and found it just as effective. When I moved over here, I continued to use Mint.com until they were no longer able to support Barclays bank, so I looked for something new. The best solution I could find was Moneydashboard.net, although I have never been completely happy with it.
Well, I finally stumbled recently across what is the best on-line solution I have found. It's Yodlee (moneycenter.yodlee.com). It has all the best features of MS Money or Quicken (like being able to split transactions for example) and it works flawlessly in multicurrency and with both UK and stateside banks and investments. Yodlee also claims to be the creator of the software that allows these types of portals to access your bank accounts in the first place, and I do find their updates to be very quick.
Anyway, if you haven't found an on-line money management solution that you're happy with, give Yodlee a look.