There were mixed feelings from my extended family about me moving over to the UK:
- sadness that we would miss out on Thanksgivings (although Skype is nice to get face-time in during THAT particular holiday)
- happiness that we would be close to my husband's fmily, who'd never met our 4 yr old son
- happiness that it seemed like a terrific adventure to a slightly exotic place (where they all speak our language
) - sadness from my job because i'd been with them for 13 years and they were going to miss me (and have to replace me)
The only REALLY bad reaction I got was from my dad, who completely lost it, shouted at me that I was ruining my life, that the loser I'd married was taking me away from a stable job, car and house, and that we'd be living like hoboes before too long. He said that due to the economy "over there", the UK was basically like Somalia and he feared for my life (I am NOT making this up)

My husband hasn't spoken to him in over a year now, since we moved over here to the Newcastle area.
Sure we gave up a lot to move here. I miss my job and the decent paycheck, but we get by and cover our bills here with no problem. I miss having large closets, electrical outlets in bathrooms, shops that stay open past 5 pm, etc...
But you know what? Our quality of life has VASTLY improved since we moved here. I get to see my family a lot more now (I used to commute 60 miles per day and NEVER saw them except on the weekends, pretty much), we get more exercise, biking and walking every day, and swimming in the ocean when we can, we live on the seafront so our location is INCREDIBLE (far better than ugly Texas), we actually eat healthier here for some reason, our son LOVES his school, and lastly, we finally have relatives who're happy to lend a hand when we need a break for a day or so, and take our son for little trips places or just a sleepover at grandma's house. Incredibly, in the past 5 years we had only 6-7 weekends for ourselves due to work, distance from family, etc...
Sorry for the long ramble, but I just wanted to say in summary: there are going to be good AND bad things that'll happen to you whether you move over here or stay put. I personally haven't had any regrets. Some things are better, some are worse, but it's all been a great experience and an adventure. I can't foresee myself moving back to the States anytime soon, if ever.