Commuting isn't a problem, necessarily, there are loads of train/tram links (and buses, if you're closer) but it might take you ages. If you're going to drive, it will definitely be longer sitting in traffic than you would want.
We live in Victoria Park, and we are going to move "closer" to town by about three blocks to right near the hospital, and I love it. I keep a horse out in Wilmslow (about 8 miles away), but because I can go up when "I" want, I can avoid 99% of the traffic and still get lovely countryside time.
The job market here really depends on the industry, I think.