Sorry I'm late to join in on this thread, but I'm an absolute podcast addict. I hope I don't derail any ongoing conversations.
Finished episode 3 of S-Town last night......Cannot wait for husband to get home to listen to episode 4....Honestly it is SO bizarre but SOOOOOO captivating for some reason.
S-Town is so good. I was listening to it in the car on a business trip with a colleague after she fell asleep. When she woke up she asked me wtf I was listening to, but I couldn't properly explain what it was "about" lol. That was at like episode 3/4 (multiple hours into the show).
If you like S-Town, you should check out This American Life. That show has been around for a really long time and their staff produced both S-Town and Serial. If you really want to nerd out, there is a podcast by AV Club (sister site of the Onion) where they analyse each episode of Serial and S-Town. It's called The Serial Serial.
Also Radiolab is a favorite of mine. They have a spin off about the Supreme Court called More Perfect.
There was a new one by NPR recently called Rough Translation which looks how things being discussed in America are happening in other countries.
WTF with Marc Maron is also great - he's an amazing interviewer and has had really huge guests on his show, including Obama as sitting president.
I could go on for a long time but I'll spare you