I live in Tower Hamlets and have for nearly a decade. I like it. We bought a flat here and when we upgrade, hoping to do so within a few years, we'll stay in TH unless our jobs change locations drastically.
Whitechapel wouldn't be my first choice within TH, but I, as a mid 30s female, feel safe there. One of our closest friends lived right by Whitechapel station with his family of 4 until very recently: husband, wife, 3 yr old daughter, 1 yr old son. The couple work opposite hours and are rarely home together. They recently moved because it's too expensive, not because they didn't like it.
What line will you be on for work?