OOH I love when I can contribute something helpful!
\ (sorry if this is a long answer!)
We just went to Egypt this past August, so only a few months ago. First of all, let me just say that you will LOVE it there! We could not believe that after seeing photos of things and the pyramids and all that we were actually standing in front of them!
We only went to Cairo so I can only offer advice about there. Of course, in Cairo, the must-see sites are the Pyramids of Giza and the Egyptian Museum. The Pyramids are amazing. You can buy additional tickets to actually enter the pyramids, but they only allow so many people per day and if you are at all claustrophobic it is pretty cramped and musty with lots of people. The large pyramid is the main one many people like to go into, but once inside you only see a small empty room. There's nothing in there. At night, there is a sound and light show on the pyramids that is popular, although we opted not to go.
I would definitely recommend taking the time to go to the Pyramids of Saqqara. They are the oldest in the world and it's a bit less touristy there. You can enter a tomb there for no additional cost and actually see the colored hieroglyphs! In that area, you can also stop by Memphis. All that is there is a giant Ramses statue and a few other things, but worth it!
Of course the museum is just amazing, and you can see the actual pharaoh mummies and King Tut's burial pieces!
We used our hotel to find a driver service to take us around the days we were there. That was very helpful as the drivers spoke English and watched out for us at the sites. There are a lot of people who will ask you to show them your tickets, etc. who are just out for a quick buck and not official guides or workers. Just be a smart traveler and ignore them and you'll be fine.
I think you'd be better of using the Egyptian pound because most people and shops used that...although I'm sure they'd take US dollars.
Feel free to PM me if you have any more specific questions! We really researched a lot before we went so I'm sure I could offer any other advice/recommendations! Check out
www.virtualtourist.com for specifics on getting around/money/sites/safety.
We stayed at the Le Meridien Pyramids...great price, great food, great service(drivers), and great views--your balcony looks out to the pyramids and at night you can see them lit up!
HAVE A GREAT TRIP!