Manchester City Centre is fab within itself, great shopping and museums. If you want to get out into the country, you are spoiled for choice, there is Arley Hall, Tatton Park, Dunham Massey, Lyme Park, The FABULOUS Jodrell Bank.
There is a small hotel in Didsbury, which is about 5 miles out of the city centre and thats a small charming-ish suburb of Manchester. That is a boutique hotel. The City Centre is lovely and small enough to spend a really lovely weekend. I LOVE Manchester!