I don't know what a standard sized meatloaf is, but the one I make which has 1 pound of minced beef, 2 oz breadcrumbs, 1 egg, half an onion, I used to cook for 1 hour in a preheated oven at gas mark 4. My new oven is Celsius and I have done it at 180 C and it was fine. This is around 350 degrees F in round numbers. Even if the loaf was a bit bigger, say a pound and a half, I would still give it an hour.