FormanFive, don't be discouraged!!
Yes, it is a lot to take in, and yes, there will definitely be hiccups and roadblocks. BUT - you have some great things going for you! You've done your research (of course, as a scientist!
). You have the resources of this forum (e.g. hms_seahorse, NW London Evangelist). It sounds like both of you are in the same mindset about this move which means you'll be able to support each other if things get tough (it's a tricky situation when one person wants to move and the other person doesn't). And you have a very healthy housing budget. The main obstacle for many getting the ideal mix of neighbourhood/property/commute is affordability, and with your budget, you'll probably have a lot more options available to you than most.
(I still will advise to choose places with as little changeovers as possible though... on a good day when everything has aligned, I can make my journey in ~45 minutes door-to-door. The extra 30-40 minutes of my typical 1.5 hour commute is largely due to waiting for the next bus or train when I change from one to another.)
I won't lie - there are some things in London that drive me off the wall. But at the end of the day, I love London.
And now I'll return you to your regularly scheduled cat and food thread.